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Diabetes

Hypoglycemia and dementia in type 2 diabetes: chick or egg?

Nature Reviews Endocrinology volume 5, pages 532–534 (2009)Cite this article

Diabetes mellitus is associated with cognitive decrements and alterations on brain imaging. However, important questions remain concerning risk factors and mechanisms for cerebral damage in patients with this condition. Data from two new studies shed new light on the relationship between hypoglycemia and cognitive dysfunction in older people with type 2 diabetes mellitus.

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References

  1. The Diabetes Control and Complications Trial Research Group. Effects of intensive diabetes therapy on neuropsychological function in adults in the Diabetes Control and Complications Trial. Ann. Intern. Med. 124, 379–388 (1996).

  2. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group et al. Long-term effect of diabetes and its treatment on cognitive function. N. Engl. J. Med. 356, 1842–1852 (2007).

  3. Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C. & Scheltens, P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 5, 64–74 (2006).

    Article  Google Scholar 

  4. Biessels, G. J., Deary, I. J. & Ryan, C. M. Cognition and diabetes: a lifespan perspective. Lancet Neurol. 7, 184–190 (2008).

    Article  Google Scholar 

  5. Whitmer, R. A., Karter, A. J., Yaffe, K., Quesenberry, C. P. Jr, & Selby, J. V. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301, 1565–1572 (2009).

    Article  CAS  Google Scholar 

  6. Bruce, D. G. et al. Severe hypoglycemia and cognitive impairment in older patients with diabetes: the Fremantle Diabetes Study. Diabetologia (2009). doi: 10.1007/s00125-009-143720131.

  7. Ryan, C. M. Why is cognitive dysfunction associated with the development of diabetes early in life? The diathesis hypothesis. Pediatr. Diabetes 7, 289–297 (2006).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, The Netherlands

    Geert Jan Biessels

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  1. Geert Jan Biessels
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Correspondence to Geert Jan Biessels.

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The author declares no competing financial interests.

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Biessels, G. Hypoglycemia and dementia in type 2 diabetes: chick or egg?. Nat Rev Endocrinol 5, 532–534 (2009). https://doi.org/10.1038/nrendo.2009.182

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