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Medical therapy for acromegaly: can we predict response?

Response to medical therapy for acromegaly is highly variable, with few predictive factors available to help clinicians make informed treatment choices. Researchers in the UK now suggest that prior radiotherapy might influence an individual's response to secondary therapy with dopamine agonists or somatostatin analogs.

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References

  1. Sherlock, M. et al. Medical therapy in patients with acromegaly: predictors of response and comparison of efficacy of dopamine agonists and somatostatin analogues. J. Clin. Endocrinol. Metab. 94, 1255–1263 (2009).

    Article  CAS  PubMed  Google Scholar 

  2. Melmed, S. et al. Guidelines for acromegaly management: an update. J. Clin. Endocrinol. Metab. 94, 1509–1517 (2009).

    Article  CAS  PubMed  Google Scholar 

  3. Melmed, S. et al. Consensus statement: medical management of acromegaly. Eur. J. Endocrinol. 153, 737–740 (2005).

    Article  CAS  PubMed  Google Scholar 

  4. Freda, P. U. et al. Long-acting somatostatin analog therapy of acromegaly: a meta-analysis. J. Clin. Endocrinol. Metab. 90, 4465–4473 (2005).

    Article  CAS  PubMed  Google Scholar 

  5. Gola, M., Bonadonna, S., Mazziotti, G., Amato, G. & Giustina, A. Resistance to somatostatin analogs in acromegaly: an evolving concept? J. Endocrinol. Invest. 29, 86–93 (2006).

    Article  CAS  PubMed  Google Scholar 

  6. Jaffe, C. A. & Barkan, A. L. Treatment of acromegaly with dopamine agonists. Endocrinol. Metab. Clin. North Am. 21, 713–735 (1992).

    Article  CAS  PubMed  Google Scholar 

  7. Giustina, A. et al. Criteria for cure of acromegaly: a consensus statement. J. Clin. Endocrinol. Metab. 85, 526–529 (2000).

    CAS  PubMed  Google Scholar 

  8. Colao, A. et al. Partial surgical removal of growth hormone-secreting pituitary tumors enhances the response to somatostatin analogs in acromegaly. J. Clin. Endocrinol. Metab. 91, 85–92 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. Bianchi, A. et al. Influence of growth hormone receptor D3 and full-length isoforms on biochemical treatment outcomes in acromegaly. J. Clin. Endocrinol. Metab. 94, 2015–2022 (2009).

    Article  CAS  PubMed  Google Scholar 

  10. Fusco, A. et al. Prognostic significance of the Ki-67 labeling index in growth hormone-secreting pituitary adenomas. J. Clin. Endocrinol. Metab. 93, 2746–2750 (2008).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Andrea Giustina.

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Andrea Giustina declares the following associations: Ipsen (consultant and speakers bureau), Italfarmaco (consultant and speakers bureau), Novartis (consultant) and Pfizer (consultant and speakers bureau).

Teresa Porcelli declares no competing interests.

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Giustina, A., Porcelli, T. Medical therapy for acromegaly: can we predict response?. Nat Rev Endocrinol 5, 425–427 (2009). https://doi.org/10.1038/nrendo.2009.146

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