Lancaster, M.A. & Knoblich, J.A. Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345, 1247125–1247125 (2014).
Yin, X. et al. Engineering stem cell organoids. Cell Stem Cell 18, 25–38 (2016).
Willyard, C. The boom in mini stomachs, brains, breasts, kidneys and more. Nature 523, 520–522 (2015).
Simian, M. & Bissell, M.J. Organoids: a historical perspective of thinking in three dimensions. J. Cell Biol. 216, 31–40 (2017).
Dutta, D., Heo, I. & Clevers, H. Disease modeling in stem cell-derived 3D organoid systems. Trends Mol. Med. 23, 393–410 (2017).
Ranga, A. et al. Neural tube morphogenesis in synthetic 3D microenvironments. Proc. Natl. Acad. Sci. USA 114, E3163 (2017).
Ma, Z. et al. Self-organizing human cardiac microchambers mediated by geometric confinement. Nat. Commun. 6, 7413 (2015).
Mohr, J.C. et al. The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials 31, 1885–1893 (2010).
Warmflash, A., Sorre, B., Etoc, F., Siggia, E.D. & Brivanlou, A.H. A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. Nat. Methods 11, 847–54 (2014).
Deglincerti, A. et al. Self-organization of human embryonic stem cells on micropatterns. Nat. Protoc. 11, 2223–2232 (2016).
Fatehullah, A., Tan, S.H. & Barker, N. Organoids as an in vitro model of human development and disease. Nat. Cell Biol. 18, 246–54 (2016).
Eiraku, M. et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472, 51–56 (2011).
Sato, T. & Clevers, H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340, 1190–1194 (2013).
Gjorevski, N. et al. Designer matrices for intestinal stem cell and organoid culture. Nature 539, 560–564 (2016).
Takasato, M. et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 536, 238–238 (2016).
Lancaster, M.A. et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379 (2013).
Li, Y., Xu, C. & Ma, T. In vitro organogenesis from pluripotent stem cells. Organogenesis 10, 159–163 (2014).
Breckwoldt, K. et al. Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat. Protoc. 12, 1177–1197 (2017).
Guo, X.M. et al. Creation of engineered cardiac tissue in vitro from mouse embryonic stem cells. Circulation 113, 2229–2237 (2006).
Shkumatov, A., Baek, K. & Kong, H. Matrix rigidity-modulated cardiovascular organoid formation from embryoid bodies. PLoS One 9, 1–10 (2014).
Sun, X. & Nunes, S.S. Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Methods 101, 21–6 (2016).
Wang, G. et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat. Med. 20, 616–623 (2014).
Mathur, A. et al. Human iPSC-based cardiac microphysiological system for drug screening applications. Sci. Rep. 5, 8883 (2015).
Ma, Z. et al. Three-dimensional filamentous human cardiac tissue model. Biomaterials 35, 1367–1377 (2014).
Hinson, J.T. et al. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science 349, 982–986 (2015).
Pettinato, G., Wen, X. & Zhang, N. Formation of well-defined embryoid bodies from dissociated human induced pluripotent stem cells using microfabricated cell-repellent microwell arrays. Sci. Rep. 4, 7402 (2014).
Nunes, S.S. et al. Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes. Nat. Methods 10, 781–787 (2013).
Bergström, G., Christoffersson, J., Schwanke, K., Zweigerdt, R. & Mandenius, C.-F. Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging. Lab Chip 15, 3242–3249 (2015).
Matsudaira, K. et al. MEMS piezoresistive cantilever for the direct measurement of cardiomyocyte contractile force. J. Micromech. Microeng. 27, 10 (2017).
Huebsch, N. et al. Miniaturized iPS-cell-derived cardiac muscles for physiologically relevant drug response analyses. Sci. Rep. 6, 24726 (2016).
Pavesi, A. et al. Controlled electromechanical cell stimulation on-a-chip. Sci. Rep. 5, 11800 (2015).
Simmons, C.S., Petzold, B.C. & Pruitt, B.L. Microsystems for biomimetic stimulation of cardiac cells. Lab Chip 12, 3235–3248 (2012).
Caiazzo, M. et al. Defined three-dimensional microenvironments boost induction of pluripotency. Nat. Mater. 15, 344–352 (2016).
Jeon, O. & Alsberg, E. Regulation of stem cell fate in a three-dimensional micropatterned dual-crosslinked hydrogel system. Adv. Funct. Mater. 23, 4765–4775 (2013).
McBeath, R., Pirone, D.M., Nelson, C.M., Bhadriraju, K. & Chen, C.S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 6, 483–495 (2004).
Musunuru, K., Domian, I.J. & Chien, K.R. Stem cell models of cardiac development and disease. Annu. Rev. Cell Dev. Biol. 26, 667–687 (2010).
Bruneau, B.G. The developmental genetics of congenital heart disease. Nature 451, 943–948 (2008).
Bressan, M. et al. Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction. Development 141, 4149–4157 (2014).
Luxán, G. et al. Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy 19, 193–201 (2013).
Lian, X. et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc. Natl. Acad. Sci. USA 109, E1848–E1857 (2012).
Huebsch, N. et al. Automated video-based analysis of contractility and calcium flux in human-induced pluripotent stem cell-derived cardiomyocytes cultured over different spatial scales. Tissue Eng. Part C Methods 21, 467–479 (2015).
Tourovskaia, A. et al. Micropatterns of chemisorbed cell adhesion-repellent films using oxygen plasma etching and elastomeric masks. Langmuir 19, 4754–4764 (2003).
Kattman, S.J. et al. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8, 228–240 (2011).
Burridge, P.W. et al. Chemically defined generation of human cardiomyocytes. Nat. Methods 11, 855–860 (2014).
Pei, F. et al. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells. Stem Cell Res. 19, 94–103 (2017).
Maddah, M. et al. A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing. Stem Cell Rep. 4, 621–631 (2015).
Lee, E.K., Kurokawa, Y.K., Tu, R., George, S.C. & Khine, M. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs. Sci. Rep. 5, 11817 (2015).