Corticotropin releasing factor (CRF) is a critical integrator of the central stress response. A new study now provides conclusive evidence that CRF-mediated forebrain activation underlies the behavioral response, such as anxiety, to stress.
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An enhanced expression of hypothalamic neuronal nitric oxide synthase in a rat model of simulated transport stress
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Mayer, E., Fanselow, M. Dissecting the components of the central response to stress. Nat Neurosci 6, 1011–1012 (2003). https://doi.org/10.1038/nn1003-1011
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DOI: https://doi.org/10.1038/nn1003-1011
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An enhanced expression of hypothalamic neuronal nitric oxide synthase in a rat model of simulated transport stress
BMC Veterinary Research (2019)