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Making scents of olfactory adaptation

Nature Neuroscience volume 7, pages 689–690 (2004)Cite this article

Olfactory neurons adapt to prolonged odor exposure through calcium-calmodulin inhibition of cyclic nucleotide-gated channels. A study in this issue reveals a new mechanism for olfactory adaptation under native conditions, via unexpected binding sites.

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Figure 1: Schematic of calmodulin interaction with the olfactory CNG ion channel, based on Bradley et al.

References

  1. Serizawa, S. et al. Science 302, 2088–2094 (2003).

    Article  CAS  Google Scholar 

  2. Fring, S. Cell. Mol. Life Sci. 58, 510–519 (2001).

    Article  Google Scholar 

  3. Chen, T.Y. & Yau, K.W. Nature 368, 545–548 (1994).

    Article  CAS  Google Scholar 

  4. Bradley, J., Bönigk, W., Yau, K.-W. & Frings, S. Nat. Neurosci. 7, 705–710 (2004).

    Article  CAS  Google Scholar 

  5. Trudeau, M.C. & Zagotta, W.N. Annu. Rev. Cell. Dev. Biol. 19, 23–44 (2003).

    Article  Google Scholar 

  6. Zheng, J. & Zagotta, W.N. Neuron 13, 411–421 (2004).

    Article  Google Scholar 

  7. Chen, T.Y. & Yau, K.W. Nature 368, 545–548 (1994).

    Article  CAS  Google Scholar 

  8. Liu, M., Chen, T.Y., Ahamed, B., Li, J. & Yau, K.W. Science 266, 1348–1354 (1994).

    Article  CAS  Google Scholar 

  9. Varnum, M.D. & Zagotta, W.N. Science 278, 110–113 (1997).

    Article  CAS  Google Scholar 

  10. Trudeau, M.C. & Zagotta, W.N. J. Biol. Chem. 278, 18705–18708 (2003).

    Article  CAS  Google Scholar 

  11. Bradley, J., Reuter, D. & Frings, S. Science 294, 2176–2178 (2001).

    Article  CAS  Google Scholar 

  12. Vetter, S.W. & Leclerc, E. Eur. J. Biochem. 270, 404–414 (2003).

    Article  CAS  Google Scholar 

  13. Sami, Y. & Kung, C. Annu. Rev. Physiol. 64, 289–311 (2002).

    Article  Google Scholar 

  14. Chin, D. & Means, A.R. Trends Cell Biol. 10, 322–328 (2000).

    Article  CAS  Google Scholar 

  15. Palfi, A. et al. Life Sci. 70, 2829–2855 (2002).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Vollum Institute, Oregon Health and Science University, Portland, 97239, Oregon, USA

    John P Adelman & Paco S Herson

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  1. John P Adelman
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  2. Paco S Herson
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Adelman, J., Herson, P. Making scents of olfactory adaptation. Nat Neurosci 7, 689–690 (2004). https://doi.org/10.1038/nn0704-689

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