Abstract
Neurotrophin–3 (NT–3) is a member of the neurotrophin family, which includes nerve growth factor (NGF), brain–derived neurotrophic factor (BDNF) and neurotrophin–4/5 (NT–4/5). These factors are crucial for development of the peripheral nervous system1, but not the central nervous system (CNS), except that NT–3 and BDNF have been implicated in the postnatal development of the cerebellum2,3. Here we created a conditional NT–3–deficient mutant, which showed abnormal cerebellar morphology.
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Acknowledgements
The authors thank Peggy Lee and Steven O'Gormann for providing reagents. B.B. also thanks Jeanne Reis and Noah Duffey for technical support and Scharam Akbarian, Larry Schwartz and Kuo Fen Lee for comments on the manuscript. This research was supported by a grant from NIH/NCI.
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Bates, B., Rios, M., Trumpp, A. et al. Neurotrophin–3 is required for proper cerebellar development. Nat Neurosci 2, 115–117 (1999). https://doi.org/10.1038/5669
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DOI: https://doi.org/10.1038/5669
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