Brief Communication | Published:

Direct recordings of grid-like neuronal activity in human spatial navigation

Nature Neuroscience volume 16, pages 11881190 (2013) | Download Citation

Abstract

Grid cells in the entorhinal cortex appear to represent spatial location via a triangular coordinate system. Such cells, which have been identified in rats, bats and monkeys, are believed to support a wide range of spatial behaviors. Recording neuronal activity from neurosurgical patients performing a virtual-navigation task, we identified cells exhibiting grid-like spiking patterns in the human brain, suggesting that humans and simpler animals rely on homologous spatial-coding schemes.

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Acknowledgements

We are grateful to the patients for participating in our study. We thank K. Lee, D. Wyeth, E. Wyeth, D. Pourshaban, E. Behnke and T. Fields for technical assistance. This work was supported by US National Institutes of Health grants MH061975 and NS033221.

Author information

Author notes

    • Itzhak Fried
    •  & Michael J Kahana

    These authors contributed equally to this work.

Affiliations

  1. School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.

    • Joshua Jacobs
    •  & Jonathan F Miller
  2. Department of Psychology, Swansea University, Swansea, UK.

    • Christoph T Weidemann
  3. Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.

    • Alec Solway
  4. Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • John F Burke
    • , Xue-Xin Wei
    •  & Michael J Kahana
  5. Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.

    • Nanthia Suthana
    •  & Itzhak Fried
  6. Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

    • Michael R Sperling
  7. Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

    • Ashwini D Sharan
  8. Functional Neurosurgery Unit, Tel-Aviv Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

    • Itzhak Fried

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Contributions

The experiment was designed by J.J., C.T.W., M.J.K., A.S. and I.F. Data were collected by J.J., C.T.W., J.F.M., J.F.B., I.F., M.R.S., A.D.S. and N.S. Data analyses were performed by J.J., X.-X.W., C.T.W., A.S. and M.J.K. J.J. and M.J.K. wrote the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Joshua Jacobs or Itzhak Fried or Michael J Kahana.

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    Supplementary Text and Figures

    Supplementary Figures 1–6 and Supplementary Tables 1–3

About this article

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DOI

https://doi.org/10.1038/nn.3466

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