What makes certain individuals more vulnerable to drug abuse than others? A study finds that potentiation of glutamatergic inputs to nucleus accumbens indirect pathway neurons may protect against compulsive drug-seeking.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Piazza, P.V. et al. Proc. Natl. Acad. Sci. USA 88, 2088–2092 (1991).
Dalley, J.W., Everitt, B.J. & Robbins, T.W. Neuron 69, 680–694 (2011).
Bock, R. et al. Nat. Neurosci. 16, 632–638 (2013).
Lobo, M.K. et al. Science 330, 385–390 (2010).
Thomas, M.J., Kalivas, P.W. & Shaham, Y. Br. J. Pharmacol. 154, 327–342 (2008).
Lüscher, C. & Malenka, R.C. Neuron 69, 650–663 (2011).
Papp, E. et al. Brain Struct. Funct. 217, 37–48 (2012).
Hnasko, T.S., Hjelmstad, G.O., Fields, H.L. & Edwards, R.H. J. Neurosci. 32, 15076–15085 (2012).
Volkow, N.D., Fowler, J.S., Wang, G.J., Baler, R. & Telang, F. Neuropharmacology 56 (suppl. 1), 3–8 (2009).
Nader, M.A. et al. Nat. Neurosci. 9, 1050–1056 (2006).
Bello, E.P. et al. Nat. Neurosci. 14, 1033–1038 (2011).
Fredholm, B.B. Exp. Cell Res. 316, 1284–1288 (2010).
Chavkin, C. Mol. Pharmacol. 83, 729–736 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Picciotto, M. An indirect resilience to addiction. Nat Neurosci 16, 521–523 (2013). https://doi.org/10.1038/nn.3375
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.3375