Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

An indirect resilience to addiction

What makes certain individuals more vulnerable to drug abuse than others? A study finds that potentiation of glutamatergic inputs to nucleus accumbens indirect pathway neurons may protect against compulsive drug-seeking.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Stronger glutamate input to indirect pathway neurons decreases motivation to work for cocaine.

References

  1. Piazza, P.V. et al. Proc. Natl. Acad. Sci. USA 88, 2088–2092 (1991).

    Article  CAS  Google Scholar 

  2. Dalley, J.W., Everitt, B.J. & Robbins, T.W. Neuron 69, 680–694 (2011).

    Article  CAS  Google Scholar 

  3. Bock, R. et al. Nat. Neurosci. 16, 632–638 (2013).

    Article  CAS  Google Scholar 

  4. Lobo, M.K. et al. Science 330, 385–390 (2010).

    Article  CAS  Google Scholar 

  5. Thomas, M.J., Kalivas, P.W. & Shaham, Y. Br. J. Pharmacol. 154, 327–342 (2008).

    Article  CAS  Google Scholar 

  6. Lüscher, C. & Malenka, R.C. Neuron 69, 650–663 (2011).

    Article  Google Scholar 

  7. Papp, E. et al. Brain Struct. Funct. 217, 37–48 (2012).

    Article  CAS  Google Scholar 

  8. Hnasko, T.S., Hjelmstad, G.O., Fields, H.L. & Edwards, R.H. J. Neurosci. 32, 15076–15085 (2012).

    Article  CAS  Google Scholar 

  9. Volkow, N.D., Fowler, J.S., Wang, G.J., Baler, R. & Telang, F. Neuropharmacology 56 (suppl. 1), 3–8 (2009).

    Article  CAS  Google Scholar 

  10. Nader, M.A. et al. Nat. Neurosci. 9, 1050–1056 (2006).

    Article  CAS  Google Scholar 

  11. Bello, E.P. et al. Nat. Neurosci. 14, 1033–1038 (2011).

    Article  CAS  Google Scholar 

  12. Fredholm, B.B. Exp. Cell Res. 316, 1284–1288 (2010).

    Article  CAS  Google Scholar 

  13. Chavkin, C. Mol. Pharmacol. 83, 729–736 (2012).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marina R Picciotto.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Picciotto, M. An indirect resilience to addiction. Nat Neurosci 16, 521–523 (2013). https://doi.org/10.1038/nn.3375

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3375

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing