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Amyloid by default

The sustained metabolic activation of the brain's default-mode network is thought to render the system vulnerable to Alzheimer's disease. Recent results with transgenic mice support this view by linking neuronal activity to interstitial fluid amyloid-β levels and the development of amyloid-β plaques.

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Figure 1: Aβ and senile plaque formation in the default mode network.


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Correspondence to Lary C Walker or Mathias Jucker.

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The authors declare no competing financial interests.

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Walker, L., Jucker, M. Amyloid by default. Nat Neurosci 14, 669–670 (2011).

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