Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neural dynamics of in vitro cortical networks reflects experienced temporal patterns

Abstract

Learning ultimately relies on changes in the flow of activity in neural microcircuits. The plasticity of neural dynamics is particularly relevant for the processing of temporal information. Chronic stimulation of cultured rat cortical networks revealed experience-dependent plasticity in neural dynamics. We observed changes in the temporal structure of activity that reflected the intervals used during training, suggesting that cortical circuits are inherently capable of temporal processing on short timescales.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Network dynamics is differentially modified by training.
Figure 2: Differential effects of training interval on neural dynamics.

References

  1. Mauk, M.D. & Buonomano, D.V. Annu. Rev. Neurosci. 27, 307–340 (2004).

    CAS  Article  PubMed  Google Scholar 

  2. Ivry, R.B. & Schlerf, J.E. Trends Cogn. Sci. 12, 273–280 (2008).

    Article  PubMed  Google Scholar 

  3. Johnson, H.A. & Buonomano, D.V. J. Neurosci. Methods 176, 136–143 (2009).

    Article  Google Scholar 

  4. Wagenaar, D.A., Pine, J. & Potter, S.M. BMC Neurosci. 7, 11 (2006).

    Article  PubMed  Google Scholar 

  5. MacLean, J.N., Watson, B.O., Aaron, G.B. & Yuste, R. Neuron 48, 811–823 (2005).

    CAS  Article  Google Scholar 

  6. Buonomano, D.V. Proc. Natl. Acad. Sci. USA 100, 4897–4902 (2003).

    CAS  Article  Google Scholar 

  7. Liu, J.K. & Buonomano, D.V. J. Neurosci. 29, 13172–13181 (2009).

    CAS  Article  Google Scholar 

  8. Fiete, I.R., Senn, W., Wang, C.Z.H. & Hahnloser, R.H.R. Neuron 65, 563–576 (2010).

    CAS  Article  Google Scholar 

  9. Karmarkar, U.R. & Dan, Y. Neuron 52, 577–585 (2006).

    CAS  Article  PubMed  Google Scholar 

  10. Wagenaar, D.A., Pine, J. & Potter, S.M. J. Negat. Results Biomed. 5, 16 (2006).

    Article  PubMed  Google Scholar 

  11. Jimbo, Y., Tateno, T. & Robinson, H.P.C. Biophys. J. 76, 670–678 (1999).

    CAS  Article  PubMed  Google Scholar 

  12. Shahaf, G. & Marom, S. J. Neurosci. 21, 8782–8788 (2001).

    CAS  Article  Google Scholar 

  13. Ruaro, M.E., Bonifazi, P. & Torre, V. IEEE Trans. Biomed. Eng. 52, 371–383 (2005).

    Article  Google Scholar 

  14. Bi, G. & Poo, M. Nature 401, 792–796 (1999).

    CAS  Article  Google Scholar 

  15. Pratt, K.G., Dong, W. & Aizenman, C.D. Nat. Neurosci. 11, 467–475 (2008).

    CAS  Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank T. Carvalho, J. Feldman, T. O'Dell and F. Schweizer for helpful discussion and comments on this manuscript. We thank K. Gurley, J. Lee and T. Lee for technical assistance. This work was supported by the National Institute of Mental Health (MH60163).

Author information

Authors and Affiliations

Authors

Contributions

H.A.J. and A.G. conducted all of the experiments. All authors participated in the data and statistical analyses. H.A.J. and D.V.B. conceived and designed the experiments and were responsible for preparing the manuscript.

Corresponding author

Correspondence to Dean V Buonomano.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–3 and Supplementary Methods (PDF 216 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Johnson, H., Goel, A. & Buonomano, D. Neural dynamics of in vitro cortical networks reflects experienced temporal patterns. Nat Neurosci 13, 917–919 (2010). https://doi.org/10.1038/nn.2579

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.2579

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing