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State dependence of olfactory perception as a function of taste cortical inactivation


As anyone who has suffered through a head cold knows, food eaten when the olfactory system is impaired tastes 'wrong', an experience that leads many to conclude that taste stimuli are processed normally only when the olfactory system is unimpaired. Evidence that the taste system influences olfactory perception, however, has been vanishingly rare. We found just such an influence; if taste cortex was inactivated when an odor was first presented, later presentations were properly appreciated only if taste cortex was again inactivated.

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Figure 1: Food preferences are socially transmitted through odor cues.
Figure 2: STFP depends on taste cortex.
Figure 3: State dependency of olfactory processing.


  1. Desgranges, B. et al. Eur. J. Neurosci. 29, 1654–1662 (2009).

    Article  Google Scholar 

  2. Kiefer, S.W. & Morrow, N.S. Behav. Neurosci. 105, 25–32 (1991).

    Article  CAS  Google Scholar 

  3. Roman, C., Nebieridze, N., Sastre, A. & Reilly, S. Behav. Neurosci. 120, 1257–1267 (2006).

    Article  Google Scholar 

  4. Balleine, B.W. & Dickinson, A. J. Neurosci. 20, 8954–8964 (2000).

    Article  CAS  Google Scholar 

  5. Jafari, M.R., Zarrindast, M.R. & Djahanguiri, B. Physiol. Behav. 88, 146–151 (2006).

    Article  CAS  Google Scholar 

  6. Katz, D.B., Simon, S.A. & Nicolelis, M.A. J. Neurosci. 21, 4478–4489 (2001).

    Article  CAS  Google Scholar 

  7. Mak, Y.E., Simmons, K.B., Gitelman, D.R. & Small, D.M. Behav. Neurosci. 119, 1693–1700 (2005).

    Article  Google Scholar 

  8. Hasan, K.S., Reddy, S.S. & Barsony, N. Endocr. Pract. 13, 716–720 (2007).

    Article  Google Scholar 

  9. Hummel, T. & Welge-Luessen, A. Adv. Otorhinolaryngol. 63, 84–98 (2006).

    PubMed  Google Scholar 

  10. Small, D.M., Gerber, J.C., Mak, Y.E. & Hummel, T. Neuron 47, 593–605 (2005).

    Article  CAS  Google Scholar 

  11. Ghazanfar, A.A. & Schroeder, C.E. Trends Cogn. Sci. 10, 278–285 (2006).

    Article  Google Scholar 

  12. Yamamoto, T., Azuma, S. & Kawamura, Y. Exp. Brain Res. 56, 23–31 (1984).

    Article  CAS  Google Scholar 

  13. Fu, W., Sugai, T., Yoshimura, H. & Onoda, N. Neuroscience 126, 1033–1041 (2004).

    Article  CAS  Google Scholar 

  14. McDonald, A.J. & Jackson, T.R. J. Comp. Neurol. 262, 59–77 (1987).

    Article  CAS  Google Scholar 

  15. Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic Press, San Diego, 2007).

    Google Scholar 

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Authors and Affiliations



Y.F.-S. performed and analyzed the experiments and wrote the manuscript with D.B.K. (who guided the experiments). B.A.R. contributed data and analysis of temporarily ageusic rats and assisted C.E.P. with the electrophysiology. S.N. performed histology and imaging experiments.

Corresponding author

Correspondence to Donald B Katz.

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Supplementary Figures 1–7, Supplementary Table 1 and Supplementary Methods (PDF 516 kb)

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Fortis-Santiago, Y., Rodwin, B., Neseliler, S. et al. State dependence of olfactory perception as a function of taste cortical inactivation. Nat Neurosci 13, 158–159 (2010).

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