Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

EBV framed in Burkitt lymphoma

Nature Medicine volume 8, pages 1086–1087 (2002)Cite this article

Epstein–Barr virus (EBV) is associated with the development of several types of cancers. Now, gene-expression profiling suggests that EBV-driven B-cell proliferation may actually drive progression to Burkitt lymphoma (pages 1098–1104).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Distinct latency programs of the EBV virus2,11.

References

  1. Crawford, D.H. Biology and disease associations of Epstein–Barr virus. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 356, 461–473 (2001).

    Article  CAS  Google Scholar 

  2. Kelly, G., Bell, A. & Rickinson, A. Epstein–Barr virus–associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2. Nature Med. 8, 1098–1104 (2002).

    Article  CAS  Google Scholar 

  3. Thorley-Lawson, D.A. Epstein–Barr virus: Exploiting the immune system. Nature Rev. Immunol. 1, 75–82 (2001).

    Article  CAS  Google Scholar 

  4. Yates, J.L., Warren, N. & Sugden, B. Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells. Nature 313, 812–815 (1985).

    Article  CAS  Google Scholar 

  5. Mosialos, G. et al. The Epstein–Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80, 389–399 (1995).

    Article  CAS  Google Scholar 

  6. Zimber-Strobl, U. et al. Epstein–Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival. EMBO J. 15, 7070–7078 (1996).

    Article  CAS  Google Scholar 

  7. Caldwell, R.G., Wilson, J.B., Anderson, S.J. & Longnecker, R. Epstein–Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity 9, 405–411 (1998).

    Article  CAS  Google Scholar 

  8. Babcock, G.J., Hochberg, D. & Thorley-Lawson, A.D. The expression pattern of Epstein–Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell. Immunity 13, 497–506 (2000).

    Article  CAS  Google Scholar 

  9. Paulson, E.J. & Speck, S.H. Differential methylation of Epstein–Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals. J. Virol. 73, 9959–9968 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Staege, M.S. et al. MYC overexpression imposes a nonimmunogenic phenotype on Epstein–Barr virus-infected B cells. Proc. Natl. Acad. Sci. USA 99, 4550–4555 (2002).

    Article  CAS  Google Scholar 

  11. Yoo, L.I. & Speck, S.H. Regulation of EBNA gene expression. Epstein–Barr Virus Report 7, 175–185 (2002).

    Google Scholar 

  12. Grossman, S.R., Johannsen, E., Tong, X., Yalamanchili, R. & Kieff, E. The Epstein–Barr virus nuclear antigen 2 transactivator is directed to response elements by the Jκ recombination signal binding protein. Proc. Natl. Acad. Sci. USA 91, 7568–7572 (1994).

    Article  CAS  Google Scholar 

  13. Henkel, T., Ling, P.D., Hayward, S.D. & Peterson, M.G. Mediation of Epstein–Barr virus EBNA2 transactivation by recombination signal-binding protein Jκ. Science 265, 92–95 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Microbiology and Immunology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia, USA

    Samuel H. Speck

Authors
  1. Samuel H. Speck
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Speck, S. EBV framed in Burkitt lymphoma. Nat Med 8, 1086–1087 (2002). https://doi.org/10.1038/nm1002-1086

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1002-1086

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing