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A rare find – cells that improve bone marrow transplantation

Nature Medicine volume 6, pages 866–867 (2000)Cite this article

A rare population of bone marrow-derived ‘facilitating cells’ promote hematopoietic stem cell engraftment without causing graft-versus-host disease, but little is known about the identity of these cells. A new facilitating cell surface marker will make them easier to study and may lead to improvements in bone marrow and solid organ transplantation (904–909 ).

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Figure 1: Facilitating cells (FCs, green) promote donor stem cell engraftment.

References

  1. Kaufman, C.L. et al. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 84, 2436–2446 ( 1994).

    CAS  Google Scholar 

  2. Schuchert, M.J., Wright, R.D. & Colson, Y.L. Characterization of a newly discovered T-cell receptor b-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment. Nature Med. 6, 904–909 (2000).

    Article  CAS  Google Scholar 

  3. Gandy, K.L., Domen, J., Aguila, H. & Weissman, I.L. CD8+TCR+ and CD8+TCR− cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 11, 579–590 (1999).

    Article  CAS  Google Scholar 

  4. Ildstad, S.T. & Sachs, D.H. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allograft or xenografts. Nature 307, 168– 170 (1984).

    Article  CAS  Google Scholar 

  5. Sykes, M. Chimerism and central tolerance. Curr. Opin. Immunol. 8, 694–703 (1996).

    Article  CAS  Google Scholar 

  6. Wekerle, T. et al. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J. Exp. Med. 187, 2037–2044 (1998).

    Article  CAS  Google Scholar 

  7. Wells, A.D. et al. Requirement for T cell apoptosis in the induction of peripheral transplantation tolerance. Nature Med. 5, 1303– 1307 (1999).

    Article  CAS  Google Scholar 

  8. Cobbold, S. & Waldmann, H. Infectious tolerance. Curr. Opin. Immunol. 10, 518–524 (1998).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine Harvard Medical School, Division of Immunology Beth Israel Deaconess Medical Center, Boston, 02215, Massachusetts

    Xian Chang Li & Terry B. Strom

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  1. Xian Chang Li
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  2. Terry B. Strom
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Li, X., Strom, T. A rare find – cells that improve bone marrow transplantation. Nat Med 6, 866–867 (2000). https://doi.org/10.1038/78621

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