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Schizophrenia: signals from the other side

Nature Medicine volume 12, pages 734–735 (2006)Cite this article

Animal models of schizophrenia are incomplete, and human brain tissue has been difficult to study. Results from postmortem human tissue begin to overcome these hurdles and find a role for modulation of NMDA type glutamate receptors (pages 824–828).

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Figure 1: A proposed mechanism for NRG1 induced hypophosphorylation of glutamate-activated NMDA type glutamate receptors in schizophrenia; this mechanism is based on studies of postmortem human prefrontal cortex by Hahn et al3.

Kim Caesar

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  1. The author is at the Columbia University College of Physicians and Surgeons, New York, 10032, New York, USA

    Gerald D Fischbach

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  1. Gerald D Fischbach
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Fischbach, G. Schizophrenia: signals from the other side. Nat Med 12, 734–735 (2006). https://doi.org/10.1038/nm0706-734

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