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CD4+ T cells: The great escape

Mutation is one way in which RNA viruses evade the destructive actions of CD8+ cytotoxic lymphocytes. New research shows that they employ the same method to escape attack by CD4+ T cells. (pages 795–800)

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Figure 1: In mammalian hosts infected with RNA viruses that continue to evolve during the course of infection, mutant viruses can emerge capable of evading or subverting one or more arms of the immune response.

Renee Lucas

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Phillips, R., Harcourt, G. & Price, D. CD4+ T cells: The great escape. Nat Med 7, 777–778 (2001). https://doi.org/10.1038/89892

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