The success of organ transplantation is severely hindered by immune-mediated rejection, but the steps involved in this process remain poorly defined. A new imaging study now reveals the sequence of events and immune cells involved in graft rejection in a mouse model, providing insights into the points at which the immune system could be rationally targeted to prevent transplant rejection (pages 744–749).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production
Respiratory Research Open Access 20 March 2012
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Miller, M.J., Hejazi, A.S., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 101, 998–1003 (2004).
Miller, M.J., Safrina, O., Parker, I. & Cahalan, M.D. J. Exp. Med. 200, 847–856 (2004).
Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Science 296, 1869–1873 (2002).
Miller, M.J., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 100, 2604–2609 (2003).
Garrod, K.R. et al. J. Immunol. 184, 2329–2336 (2010).
Cahalan, M.D. & Parker, I. Annu. Rev. Immunol. 26, 585–626 (2008).
Sen, D., Forrest, L., Kepler, T.B., Parker, I. & Cahalan, M.D. Proc. Natl. Acad. Sci. USA 107, 8334–8339 (2010).
Matheu, M.P. et al. Immunity 29, 602–614 (2008).
Celli, S. et al. Nat. Med. 17, 744–749 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Cahalan, M. Imaging transplant rejection: a new view. Nat Med 17, 662–663 (2011). https://doi.org/10.1038/nm0611-662
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0611-662
This article is cited by
-
Neuropilin‐1+ regulatory T cells promote skin allograft survival and modulate effector CD4+ T cells phenotypic signature
Immunology & Cell Biology (2015)
-
Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production
Respiratory Research (2012)