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Interleukin-17A is not expressed by CD207+ cells in Langerhans cell histiocytosis lesions

Nature Medicine volume 15, pages 483–484 (2009)Cite this article

To the Editor:

In a recent issue of Nature Medicine, Coury et al.1 identified a potentially interesting role for interleukin-17 (IL-17A), a proinflammatory cytokine, in the pathogenesis of Langerhans cell histiocytosis (LCH). LCH is a disease characterized by lesions containing CD207+ (langerin+) histiocytes. However, as shown here, we were unable to identify IL17A gene expression in Langerhans cell lesions, and plasma concentrations of IL-17A did not correlate with disease activity. Therefore, our study does not support a central role for IL-17A in LCH pathogenesis.

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Figure 1: Cell-specific IL17A expression.
Figure 2: IL-17A plasma concentrations, as determined by ELISA.

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Acknowledgements

We would like to thank B. Myones (Baylor College of Medicine) for the juvenile idiopathic arthritis plasma sample and helpful discussions. This project was supported by grants from the Histiocytosis Association of America, the US National Institutes of Health (R21 CA 114981-01A2), the American Society of Clinical Oncology and the Thrasher Research Fund. C.E.A. received funding from the US National Institutes of Health Pediatric Oncology Research Training Grant (T32 CA115303-03).

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Authors and Affiliations

  1. Texas Children's Hospital Cancer Center and Hematology Service, Houston, Texas, USA

    Carl E Allen & Kenneth L McClain

  2. Baylor College of Medicine, Houston, Texas, USA

    Carl E Allen & Kenneth L McClain

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  1. Carl E Allen
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  2. Kenneth L McClain
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Allen, C., McClain, K. Interleukin-17A is not expressed by CD207+ cells in Langerhans cell histiocytosis lesions. Nat Med 15, 483–484 (2009). https://doi.org/10.1038/nm0509-483

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