A new mouse model suggests that genomic instability leads to neuronal cell death in Nijmegen breakage syndrome—a neurological disease associated with predisposition to cancer. Impairing ATM or p53 function in the mice holds cell death at bay, restoring normal neurological function despite persistent genetic abnormalities (pages 538–544).
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Barlow, C., Treuner, K. DNA instability in the brain: survival of the 'fittest'. Nat Med 11, 474–475 (2005). https://doi.org/10.1038/nm0505-474
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DOI: https://doi.org/10.1038/nm0505-474