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For want of a disc, the cell was lost….

Possible links between photoreceptor disc defects, light damage and a rhodopsin-mediated death signal clarify the connection between a diverse set of retinal insults and apoptotic cell death.

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Figure 1: Constant exposure to damaging reactive oxygen species and light photons can lead to activation of apoptotic pathways in photoreceptors, mediated by outer segment shortening and disorganization or rhodopsin photoproducts3,5,6.

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Wright, A. For want of a disc, the cell was lost….. Nat Med 6, 508–510 (2000). https://doi.org/10.1038/74985

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