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Profiling familial breast cancer

Nature Medicine volume 7, pages 408–410 (2001)Cite this article

Microarray analysis can be used to differentiate gene expression patterns between various types of tumors, including breast tumors caused by BRCA1 and BRCA2 mutations. But what must be done before this technology can be used in the clinic?

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Figure 1: Morphology of breast cancer associated with BRCA1 mutations.
Figure 2: Bar graph showing the distribution of overall histological grade in tumors associated with BRCA1 and BRCA2 mutations, compared with sporadic tumors.
Figure 3: a-c, Gene-expression array data and multidimensional scaling plot as used by Hedenfalk et al.3

Courtesy of The New England Journal of Medicine

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Authors and Affiliations

  1. The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK

    Sunil R. Lakhani & Alan Ashworth

  2. The Ludwig Institute for Cancer Research, London, UK

    Michael J. O'Hare

Authors
  1. Sunil R. Lakhani
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  2. Michael J. O'Hare
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  3. Alan Ashworth
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Lakhani, S., O'Hare, M. & Ashworth, A. Profiling familial breast cancer. Nat Med 7, 408–410 (2001). https://doi.org/10.1038/86464

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