Targeted stimulation of the spinal cord to restore locomotor activity

A new study has located 'hot spots' in the rat spinal cord that are associated with leg flexion and extension in rats. Electrical stimulation applied in an alternating pattern between these hot spots facilitated locomotion after the hindlimbs were paralyzed as a result of spinal cord injury (SCI).

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Figure 1: Wenger et al.8 were able to identify hot spots on the epidural surface of the spinal cords of rats where epidural stimulation (ES) elicited flexion and extension.

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Correspondence to Arthur Prochazka.

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Prochazka, A. Targeted stimulation of the spinal cord to restore locomotor activity. Nat Med 22, 125–126 (2016). https://doi.org/10.1038/nm.4043

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