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A spinal cord injury consists of damage to the spinal cord that results from external trauma including accidents, falls and sports-related injuries, rather than a degenerative disease. The effects of a spinal cord injury widely vary from no effect, to pain, or to complete loss of spinal cord function.
Electrical signals with characteristic parameters for reconstructing neural circuits remain incompletely understood, limiting the therapeutic potential of electrical neuromodulation techniques. Here, the authors demonstrate that dual electrical stimulation at 10–20 Hz rebuilds the spinal sensorimotor neural circuit after spinal cord injury, indicating the characteristic signals of circuit remodeling.
Electrical stimulation of the neuromuscular system holds promise for therapeutic biomedical applications, but is currently restricted by power. Here, the authors introduce fully implantable resonator-based designs achieving ±20 V compliance and >300 mW output, enabling multichannel, biphasic, current-controlled operation to evoke functional gate patterns for 6-weeks in freely behaving rats.
Spiny mice (Acomys cahirinus) are revealed to recover motor co-ordination following complete spinal cord transection, owing to regrowth of axonal motor pathways across the lesion site.
Regenerative neurogenesis after spinal cord injury in zebrafish involves TNF signalling between lesion-activated macrophages and spinal progenitor cells.