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A B cell–dependent mechanism restrains T cell transendothelial migration

A new study reveals that B cells restrict the transendothelial migration of T cells in physiological inflammation in response to adiponectin, but that this mechanism is compromised in autoimmunity and is hence a novel avenue for therapy development.

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Figure 1: The role of B cells in S1P-mediated regulation of T cell trafficking.

Kim Caesar/Nature Publishing Group


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Correspondence to Julie D Saba.

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Saba, J. A B cell–dependent mechanism restrains T cell transendothelial migration. Nat Med 21, 424–426 (2015).

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