Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Huntington's disease: easing the NMDAR traffic jam

Excitatory neurotransmission through NMDA receptors (NMDARs) has a pivotal role in healthy brain function, and its dysfunction has long been implicated in the pathogenesis of neurodegenerative disorders, including Huntington's disease. A new study uncovers a molecular link between mutant huntingtin and aberrant trafficking of an unconventional NDMAR subunit (GluN3A). Targeting this disease mechanism in a Huntington's disease mouse model had multiple therapeutic benefits (pages 1030–1038).

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Aberrant mHtt interaction with PACSIN1 impairs endocytosis of the NMDAR subunit GluN3A at synapses in Huntington's disease.

Marina Corral Spence


  1. Raymond, L.A. et al. Neuroscience 198, 252–273 (2011).

    Article  CAS  Google Scholar 

  2. Marco, S. et al. Nat. Med. 19, 1030–1038 (2013).

    Article  CAS  Google Scholar 

  3. Ross, C.A. & Tabrizi, S.J. Lancet Neurol. 10, 83–98 (2011).

    Article  CAS  Google Scholar 

  4. Shirasaki, D.I. et al. Neuron 75, 41–57 (2012).

    Article  CAS  Google Scholar 

  5. Sanz-Clemente, A., Nicoll, R.A. & Roche, K.W. Neuroscientist 19, 62–75 (2013).

    Article  CAS  Google Scholar 

  6. Newpher, T.M. & Ehlers, M.D. Neuron 58, 472–497 (2008).

    Article  CAS  Google Scholar 

  7. Das, S. et al. Nature 393, 377–381 (1998).

    Article  CAS  Google Scholar 

  8. Milnerwood, A.J. et al. Neuron 65, 178–190 (2010).

    Article  CAS  Google Scholar 

  9. Okamoto, S. et al. Nat. Med. 15, 1407–1413 (2009).

    Article  CAS  Google Scholar 

  10. Pérez-Otaño, I. et al. Nat. Neurosci. 9, 611–621 (2006).

    Article  Google Scholar 

  11. Modregger, J. et al. Hum. Mol. Genet. 11, 2547–2558 (2002).

    Article  CAS  Google Scholar 

  12. Southwell, A.L. et al. J. Neurosci. 28, 9013–9020 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to X William Yang.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Daggett, A., Yang, X. Huntington's disease: easing the NMDAR traffic jam. Nat Med 19, 971–973 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing