A new study provides an example of the delicate balance between stem cell migration, differentiation and maintenance in the context of skin wounding. In mice, wounding or ultraviolet irradiation induces melanocyte stem cells in the hair follicle to leave their niche before cell division and migrate up the follicle to differentiate into functional melanocytes, thus providing a protective pigmented barrier (pages 924–929).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Olfactory receptor OR2AT4 regulates human hair growth
Nature Communications Open Access 18 September 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ito, M. et al. Nat. Med. 11, 1351–1354 (2005).
Plikus, M.V. et al. Semin. Cell Dev. Biol. 23, 946–953 (2012).
Slominski, A., Paus, R. & Schadendorf, D. J. Theor. Biol. 164, 103–120 (1993).
Wood, J.M. et al. Exp. Dermatol. 8, 153–164 (1999).
Plonka, P.M. et al. Exp. Dermatol. 18, 799–819 (2009).
Chou, W.C. et al. Nat. Med. 19, 924–929 (2013).
Nishimura, E.K. Pigment Cell Melanoma Res. 24, 401–410 (2011).
Peters, E.M. et al. J. Histochem. Cytochem. 50, 751–766 (2002).
Ansell, D.M. et al. J. Invest. Dermatol. 131, 518–528 (2011).
Slominski, A., Wortsman, J., Tuckey, R.C. & Paus, R. Mol. Cell. Endocrinol. 265–266, 143–149 (2007).
Ito, N. et al. FASEB J. 19, 1332–1334 (2005).
Lu, Z. et al. Exp. Dermatol. 16, 37–44 (2007).
Grichnik, J.M. J. Invest. Dermatol. 128, 2365–2380 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
R.P. runs several industry-sponsored (Unilever, Henkel, Giuliani, Wolff, Braun, Follicum) skin and hair research projects unrelated to hair or skin pigmentation and serves as consultant on skin and hair research matters for industry (Giuliani, Wolff, Chelac).
Rights and permissions
About this article
Cite this article
Paus, R. Migrating melanocyte stem cells: masters of disaster?. Nat Med 19, 818–819 (2013). https://doi.org/10.1038/nm.3264
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3264
This article is cited by
-
Olfactory receptor OR2AT4 regulates human hair growth
Nature Communications (2018)
-
A Synthetic Sandalwood Odorant Induces Wound-Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4
Journal of Investigative Dermatology (2014)