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Sorting receptors at Down's syndrome synapses

Nature Medicine volume 19, pages 404–406 (2013)Cite this article

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Trisomy 21 triggers multiple potential routes to intellectual disability in Down's syndrome. A new study suggests that aberrant endosomal function may contribute to the neuronal deficits behind learning and memory impairments in affected individuals (pages 473–480).

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Figure 1: A route from trisomy 21 to synaptic dysfunction in Down's syndrome.

Katie Vicari

References

  1. Cataldo, A.M. et al. Am. J. Pathol. 157, 277–286 (2000).

    Article  CAS  Google Scholar 

  2. Ginsberg, S.D. et al. Biol. Psychiatry 68, 885–893 (2010).

    Article  CAS  Google Scholar 

  3. Siegenthaler, B.M. & Rajendran, L. Neurodegener. Dis. 10, 116–121 (2012).

    Article  CAS  Google Scholar 

  4. Wang, X. et al. Nat. Med. 19, 473–480 (2013).

    Article  CAS  Google Scholar 

  5. Cullen, P.J. & Korswagen, H.C. Nat. Cell Biol. 14, 29–37 (2011).

    Article  Google Scholar 

  6. Muhammad, A. et al. Proc. Natl. Acad. Sci. USA 105, 7327–7332 (2008).

    Article  CAS  Google Scholar 

  7. Elton, T.S., Sansom, S.E. & Martin, M.M. RNA Biol. 7, 540–547 (2010).

    Article  CAS  Google Scholar 

  8. Elton, T.S., Selemon, H., Elton, S.M. & Parinandi, N.L. Gene published online, http://dx.doi.org/10.1016/j.gene.2012.12.009 (13 December 2012).

  9. Kuhn, D.E. et al. J. Biol. Chem. 285, 1529–1543 (2010).

    Article  CAS  Google Scholar 

  10. He, M., Xu, Z., Ding, T., Kuang, D.M. & Zheng, L. Cell Mol. Immunol. 6, 343–352 (2009).

    Article  CAS  Google Scholar 

  11. Edgin, J.O., Mason, G.M., Spano, G., Fernandez, A. & Nadel, L. Prog. Brain Res. 197, 123–151 (2012).

    Article  Google Scholar 

  12. Kleschevnikov, A.M. et al. J. Neurosci. 32, 9217–9227 (2012).

    Article  CAS  Google Scholar 

  13. Salehi, A. et al. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci. Transl. Med. 1, 7ra17 (2009).

    Article  CAS  Google Scholar 

  14. Steinberg, F. et al. Nat. Cell Biol. (in the press).

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  1. Matt W. Jones is at the School of Physiology & Pharmacology, University of Bristol, Bristol, UK.,

    Matt W Jones

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  1. Matt W Jones
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Correspondence to Matt W Jones.

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The author declares no competing financial interests.

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Jones, M. Sorting receptors at Down's syndrome synapses. Nat Med 19, 404–406 (2013). https://doi.org/10.1038/nm.3152

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