Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Ephrin receptor: a door to KSHV infection

Nature Medicine volume 18, pages 861–863 (2012)Cite this article

Subjects

Kaposi's sarcoma–associated herpesvirus is a major oncogenic virus that has been implicated in human cancers. A new study identifies ephrin receptor A2 as a key host receptor for this virus that permits infection of endothelial cells (pages 961–966).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Ephrin signaling and KSHV entry.

References

  1. Hahn, A. et al. Nat. Med. 18, 961–966 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chakraborty, S., Veettil, M.V., Bottero, V. & Chandran, B. Proc. Natl. Acad. Sci. USA 109, 1163–1172 (2012).

    Article  Google Scholar 

  3. Hirai, H., Maru, Y., Hagiwara, K., Nishida, J. & Takaku, F. Science 238, 1717–1720 (1987).

    Article  CAS  PubMed  Google Scholar 

  4. Wang, H.U., Chen, Z.F. & Anderson, D.J. Cell 93, 741–753 (1998).

    Article  CAS  PubMed  Google Scholar 

  5. Zelinski, D.P., Zantek, N.D., Stewart, J.C., Irizarry, A.R. & Kinch, M.S. Cancer Res. 61, 2301–2306 (2001).

    CAS  PubMed  Google Scholar 

  6. Dobrzanski, P. et al. Cancer Res. 64, 910–919 (2004).

    Article  CAS  PubMed  Google Scholar 

  7. Wang, H.W. et al. Nat. Genet. 36, 687–693 (2004).

    Article  CAS  PubMed  Google Scholar 

  8. Mäkinen, T. et al. Genes Dev. 19, 397–410 (2005).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lupberger, J. et al. Nat. Med. 17, 589–595 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Negrete, O.A. et al. Nature 436, 401–405 (2005).

    Article  CAS  PubMed  Google Scholar 

  11. Bonaparte, M.I. et al. Proc. Natl. Acad. Sci. USA 102, 10652–10657 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. Akula, S.M., Wang, F.Z., Vieira, J. & Chandran, B. Virology 282, 245–255 (2001).

    Article  CAS  PubMed  Google Scholar 

  13. Rappocciolo, G. et al. J. Immunol. 176, 1741–1749 (2006).

    Article  CAS  PubMed  Google Scholar 

  14. Akula, S.M., Pramod, N.P., Wang, F.Z. & Chandran, B. Cell 108, 407–419 (2002).

    Article  CAS  PubMed  Google Scholar 

  15. Veettil, M.V. et al. J. Virol. 82, 12126–12144 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Kaleeba, J.A.R. & Berger, E.A. Science 311, 1921–1924 (2006).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chris Boshoff is at the UCL Cancer Institute, University College London, London.,

    Chris Boshoff

Authors
  1. Chris Boshoff
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chris Boshoff.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boshoff, C. Ephrin receptor: a door to KSHV infection. Nat Med 18, 861–863 (2012). https://doi.org/10.1038/nm.2803

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2803

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer