Sigal, A. et al. Nature 477, 95–98 (2011).
The authors propose a model to explain how an HIV reservoir can be maintained even in the face of antiretroviral therapy, via cell-to-cell spread of the virus, which could result in multiple viral infections per cell. They also provide evidence to support their model in vitro.
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Swami, M. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nat Med 17, 1199 (2011). https://doi.org/10.1038/nm.2522
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DOI: https://doi.org/10.1038/nm.2522
