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An in-depth review compiling information about the effects of virus infections in protists and discussing how these interactions are important for cell biology, ecology and biotechnology.
HCMV induces a senescence-associated secretory phenotype (SASP)-like inflammatory response in renal but not retinal cells, potentially driving kidney pathogenesis through an IL-6-dependent senescence loop in neighboring uninfected cells.
Here, the authors identify neuron-specific miR-9 that potentially blocks HSV-1 neuronal replication by targeting host OCT-1 and ONECUT transcription factors involved in epigenetic activation of HSV-1 productive-cycle genes. Thus miR-9 promotes viral epigenetic silencing and latent infection in neurons.
Gut ecosystem colonization impacts lifelong health. Here, authors track mother-infant gut viruses over time, reveal feeding’s influence on early viral colonization, and demonstrate the co-transmission of bacteriophages and bacteria from mothers to infants.
Human cytomegalovirus (HCMV) is a ubiquitous pathogen associated with morbidity and mortality in the immunocompromised or immunonaive context. Here the authors show that HCMV exploits STING signalling and subverts the interferon response to support infection of monocyte derive dendritic cells.
There are limited treatment options for infection with Crimean-Congo hemorrhagic fever virus in humans. Here, the authors show that a monoclonal antibody targeting the highly conserved viral nucleocapsid protein provides protective effects in a mouse model of infection.
A participatory research initiative generates actionable data on avian diseases in New York City, showcases how a community-based approach can tackle misinformation, and actively engages students from historically underrepresented communities in science, technology, engineering and maths.
We find that people with non-suppressible human immunodeficiency virus (HIV) viremia despite antiretroviral therapy (ART) exhibit several distinguishing features. These include expanded CD4+ T cell clones containing HIV proviruses integrated into transcriptionally permissive regions, the presence of certain proviral defects or human leukocyte antigen (HLA)-escape mutations, enhanced survival signatures, and muted interferon and cytotoxic CD8+ T cell responses.
This study reports the identification of an archaeal virus Acr protein that blocks the dissociation of the target RNA from the type III-B CRISPR–Cas effector complex, which prevents the recycling of the complex.
In this Journal Club, Chelsey Spriggs discusses how the study of simian virus 40 (SV40) revealed a key sequence in the large T antigen that directs its transport into the cell nucleus, advancing our understanding of nuclear import mechanics.
This study shows that intercellular long extensions promote the evasion of antibody neutralization and the efficient intercellular transmission of chikungunya virus in vitro and in vivo.