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EGFR signaling in podocytes at the root of glomerular disease

A study in a mouse model of immune-mediated glomerular disease and in people with rapidly progressive glomerulonephritis shows activation of epidermal growth factor receptor (EFGR) signaling in podocytes by a molecule expressed in the kidney (pages 1242–1250). Blocking this axis may open new doors to treat inflammatory kidney conditions.

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Figure 1: Activation of the EGFR pathway by HB-EGF in the glomerulus in RPGN.

Katie Vicari

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Correspondence to Ray Harris.

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Harris, R. EGFR signaling in podocytes at the root of glomerular disease. Nat Med 17, 1188–1189 (2011). https://doi.org/10.1038/nm.2455

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