Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

EGFR signaling in podocytes at the root of glomerular disease

A study in a mouse model of immune-mediated glomerular disease and in people with rapidly progressive glomerulonephritis shows activation of epidermal growth factor receptor (EFGR) signaling in podocytes by a molecule expressed in the kidney (pages 1242–1250). Blocking this axis may open new doors to treat inflammatory kidney conditions.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Activation of the EGFR pathway by HB-EGF in the glomerulus in RPGN.

Katie Vicari


  1. Thorner, P.S., Ho, M., Eremina, V., Sado, Y. & Quaggin, S. J. Am. Soc. Nephrol. 19, 495–502 (2008).

    Article  Google Scholar 

  2. Bollée, G. et al. Nat. Med. 17, 1242–1250 (2011).

    Article  Google Scholar 

  3. Citri, A. & Yarden, Y. Nat. Rev. Mol. Cell Biol. 7, 505–516 (2006).

    Article  CAS  Google Scholar 

  4. Avraham, R. & Yarden, Y. Nat. Rev. Mol. Cell Biol. 12, 104–117 (2011).

    Article  CAS  Google Scholar 

  5. Harris, R.C., Chung, E. & Coffey, R.J. Exp. Cell Res. 284, 2–13 (2003).

    Article  CAS  Google Scholar 

  6. Zeng, F., Singh, A.B. & Harris, R.C. Exp. Cell Res. 315, 602–610 (2009).

    Article  CAS  Google Scholar 

  7. Lautrette, A. et al. Nat. Med. 11, 867–874 (2005).

    Article  CAS  Google Scholar 

  8. Pillebout, E. et al. J. Clin. Invest. 112, 843–852 (2003).

    Article  CAS  Google Scholar 

  9. Laouari, D. et al. J. Am. Soc. Nephrol. 22, 327–335 (2011).

    Article  CAS  Google Scholar 

  10. Sakai, M. et al. J. Clin. Invest. 99, 2128–2138 (1997).

    Article  CAS  Google Scholar 

  11. Feng, L. et al. J. Clin. Invest. 105, 341–350 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ray Harris.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Harris, R. EGFR signaling in podocytes at the root of glomerular disease. Nat Med 17, 1188–1189 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing