CD4 is almost universally required for HIV to enter cells. A mutable disulfide bond of CD4, however, can influence the permissiveness of cells to HIV infection.
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Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection
Retrovirology Open Access 03 December 2012
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Goldsmith, M., Doms, R. HIV entry: are all receptors created equal?. Nat Immunol 3, 709–710 (2002). https://doi.org/10.1038/ni819
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DOI: https://doi.org/10.1038/ni819
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