The survival of naive CD8+ T cells depends on the receipt of 'tonic' T cell receptor signals, but overt self-reactivity must be avoided. New work traces an intricate regulatory loop responsible for 'tuning' CD8 coreceptor expression to a 'balance point' appropriate for each T cell receptor.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Kim Caesar
References
Surh, C.D. & Sprent, J. Semin. Immunol. 17, 183–191 (2005).
Park, J.H. et al. Nat. Immunol. 8, 1049–1059 (2007).
Schluns, K.S., Kieper, W.C., Jameson, S.C. & Lefrancois, L. Nat. Immunol. 1, 426–432 (2000).
Teh, H.S., Kishi, H., Scott, B. & Von Boehmer, H. J. Exp. Med. 169, 795–806 (1989).
Maile, R. et al. J. Immunol. 174, 619–627 (2005).
Park, J.H. et al. Immunity 21, 289–302 (2004).
Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F. & Littman, D.R. Immunity 7, 537–547 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zúñiga-Pflücker, J. CD8+ T cells are kept in tune by modulating IL-7 responsiveness. Nat Immunol 8, 1027–1028 (2007). https://doi.org/10.1038/ni1007-1027
Issue Date:
DOI: https://doi.org/10.1038/ni1007-1027
This article is cited by
-
Co-receptor tuning
Nature Reviews Immunology (2007)
