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Vascular targeting and antigen presentation

Nature Immunology volume 2, pages 567–568 (2001)Cite this article

The activation of macrophages, dendritic cells and other APCs depends on antigen binding to membrane surface receptors followed by internalization, intracellular processing and presentation. Several recent studies have focused on antigen targeting to APCs1,2,3. Two different approaches have been explored. In one approach, specific ligand-receptor pairs such as gp96-CD913 and OmpA-TLR21 were used for antigen targeting. In another approach, selective stimulation with soluble factors was used: monocytes were targeted by switching-on IL-6–dependent differentiation into macrophages2. The latter strategy seems to recapitulate steps that occur when monocytes cross the vascular endothelium. These findings suggest that it is possible to target APCs as a strategy for augmenting or suppressing the immune response.

Although the approaches described above use classical APCs, other cell types—such as those that form blood vessels—may also be used. The advantages of targeting endothelial cells have not been fully appreciated, even though the antigen-presenting function of endothelial cells is well documented4,5,6,7,8. Indeed, it may be possible to modulate the immune response by exploiting the molecular diversity of the vascular endothelium for the purposes of cell-specific targeting9,10,11,12,13.

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Authors and Affiliations

  1. The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, TX, USA

    Renata Pasqualini & Wadih Arap

  2. University of California, San Francisco, San Francisco, 94143-0130, CA, USA

    Donald M. McDonald

  3. Renata Pasqualini

  4. Wadih Arap

Authors
  1. Renata Pasqualini
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  2. Donald M. McDonald
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  3. Wadih Arap
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Pasqualini, R., McDonald, D. & Arap, W. Vascular targeting and antigen presentation. Nat Immunol 2, 567–568 (2001). https://doi.org/10.1038/89704

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