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Caspase activation is not death

Nature Immunology volume 4, pages 308–310 (2003)Cite this article

Is apoptotic cell death due to the action of caspases? Caspase inhibition can actually encourage death in tumor necrosis factor–induced shock, indicating that caspase activation is not synonymous with apoptotic demise.

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Figure 1: Role of caspases in signal transduction.

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Authors and Affiliations

  1. Centre National de la Recherche Scientifique, UMR8125, Institut Gustave Roussy, 39 rue Camille-Desmoulins, Villejuif, F-94805, France

    Jean-Luc Perfettini & Guido Kroemer

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  1. Jean-Luc Perfettini
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  2. Guido Kroemer
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Correspondence to Guido Kroemer.

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Perfettini, JL., Kroemer, G. Caspase activation is not death. Nat Immunol 4, 308–310 (2003). https://doi.org/10.1038/ni0403-308

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