News & Views | Published:

B cell lineages: documented at last!

Functional and phenotypic distinctions characterize B-1 cells versus B-2 cells. The identification of adult bone marrow cells that give rise exclusively to B-1 B cells support earlier ideas regarding the existence of dedicated B-1 progenitors.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Montecino-Rodriguez, E., Leathers, A. & Dorshkind, K. Nat. Immunol. 7, 293–301 (2006).

  2. 2

    Herzenberg, L.A. Cell 59, 953–954 (1989).

  3. 3

    Baumgarth, N., Tung, J.W. & Herzenberg, L.A. Springer Semin. Immunopathol. 26, 347–362 (2005).

  4. 4

    Kantor, A.B. & Herzenberg, L.A. Annu. Rev. Immunol. 11, 501–538 (1993).

  5. 5

    Kawikova, I. et al. Immunology 113, 234–245 (2004).

  6. 6

    Alugupalli, K.R. & Gerstein, R.M. Immunity 23, 1–2 (2005).

  7. 7

    Haas, K.M., Poe, J.C., Steeber, D.A. & Tedder, T.F. Immunity 23, 7–18 (2005).

  8. 8

    Hardy, R.R. & Hayakawa, K. Proc. Natl. Acad. Sci. USA 88, 11550–11554 (1991).

  9. 9

    Herzenberg, L.A. Immunol. Rev. 175, 9–21 (2000).

  10. 10

    Berland, R. & Wortis, H.H. Annu. Rev. Immunol. 20, 253–300 (2002).

  11. 11

    Lam, K.P. & Rajewsky, K. J. Exp. Med. 190, 471–477 (1999).

  12. 12

    Tung, J.W., Mrazek, M.D., Yang, Y., Herzenberg, L.A. & Herzenberg, L.A. Proc. Natl. Acad. Sci. USA (in press).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Figure 1: The development of three distinct B cell lineages in the layered immune system in the mouse.