Functional and phenotypic distinctions characterize B-1 cells versus B-2 cells. The identification of adult bone marrow cells that give rise exclusively to B-1 B cells support earlier ideas regarding the existence of dedicated B-1 progenitors.
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Herzenberg, L., Tung, J. B cell lineages: documented at last!. Nat Immunol 7, 225–226 (2006). https://doi.org/10.1038/ni0306-225
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DOI: https://doi.org/10.1038/ni0306-225
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