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A move to exclude

It is not clear how lymphocytes establish monoallelic gene expression of antigen receptor genes. New data linking local chromatin modifications with nuclear movements provide a framework for deciphering this process.

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Figure 1: Igh locus nuclear dynamics and relationship to histone modification changes during B cell differentiation.

Erin Boyle

References

  1. Roldan, E. et al. Nat. Immunol. 6, 31–41 (2005).

    Article  CAS  Google Scholar 

  2. Goldmit, M. et al. Nat. Immunol. 6, 198–203 (2005).

    Article  CAS  Google Scholar 

  3. Chowdhury, D. & Sen, R. Immunity 18, 229–241 (2003).

    Article  CAS  Google Scholar 

  4. Kosak, S.T. et al. Science 296, 158–162 (2002).

    Article  CAS  Google Scholar 

  5. Johnson, K. et al. Nat. Immunol. 5, 853–861 (2004).

    Article  CAS  Google Scholar 

  6. Chowdhury, D. & Sen, R. EMBO J. 20, 6394–6403 (2001).

    Article  CAS  Google Scholar 

  7. Bolland, D.J. et al. Nat. Immunol. 5, 630–637 (2004).

    Article  CAS  Google Scholar 

  8. Bergman, Y., Fisher, A. & Cedar, H. Curr. Opin. Immunol. 15, 176–181 (2003).

    Article  CAS  Google Scholar 

  9. Hesslein, D.G. et al. Genes Dev. 17, 37–42 (2003)

    Article  CAS  Google Scholar 

  10. Fuxa, M. et al. Genes Dev. 18, 411–422 (2004)

    Article  CAS  Google Scholar 

  11. Shaffer, A.L., Peng, A. & Schlissel, M.S. Immunity 6, 131–143 (1997).

    Article  CAS  Google Scholar 

  12. Liang, H.E., Hsu, L.Y., Cado, D. & Schlissel, M.S. Cell 118, 19–29 (2004).

    Article  CAS  Google Scholar 

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Sen, R. A move to exclude. Nat Immunol 6, 128–130 (2005). https://doi.org/10.1038/ni0205-128

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