HLA-Fatal attraction

Open conformers of the non-classical and monomorphic major histocompatibility complex (MHC) class I molecule HLA-F are ligands for the activating receptor KIR3DS1 and trigger the activation of natural killer (NK) cells.

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Figure 1: Open conformers of HLA-F further expand the list of ligands for activating KIRs.

References

  1. 1

    Parham, P. Immunol. Rev. 267, 1–5 (2015).

    Article  Google Scholar 

  2. 2

    Della Chiesa, M., Sivori, S., Carlomagno, S., Moretta, L. & Moretta, A. Front. Immunol. 6, 573 (2015).

    Article  Google Scholar 

  3. 3

    Garcia-Beltran, W.F. Nat Immunol 17, 1067–1074 (2016).

    CAS  Article  Google Scholar 

  4. 4

    Vivier, E., Nunès, J.A. & Vély, F. Science 306, 1517–1519 (2004).

    CAS  Article  Google Scholar 

  5. 5

    Goodridge, J.P., Burian, A., Lee, N. & Geraghty, D.E. J. Immunol. 191, 3553–3562 (2013).

    CAS  Article  Google Scholar 

  6. 6

    Lepin, E.J. et al. Eur. J. Immunol. 30, 3552–3561 (2000).

    CAS  Article  Google Scholar 

  7. 7

    Lee, N., Ishitani, A. & Geraghty, D.E. Eur. J. Immunol. 40, 2308–2318 (2010).

    CAS  Article  Google Scholar 

  8. 8

    Raulet, D.H., Gasser, S., Gowen, B.G., Deng, W. & Jung, H. Annu. Rev. Immunol. 31, 413–441 (2013).

    CAS  Article  Google Scholar 

  9. 9

    Martin, M.P. et al. Nat. Genet. 31, 429–434 (2002).

    CAS  Article  Google Scholar 

  10. 10

    Pascal, V. et al. J. Immunol. 179, 1625–1633 (2007).

    CAS  Article  Google Scholar 

  11. 11

    Ishigami, S. et al. Anticancer Res. 35, 2279–2285 (2015).

    CAS  PubMed  Google Scholar 

  12. 12

    Harada, A. et al. Pathol. Int. 65, 569–574 (2015).

    CAS  Article  Google Scholar 

  13. 13

    Jucaud, V. et al. Clin. Exp. Immunol. 183, 326–340 (2016).

    CAS  Article  Google Scholar 

  14. 14

    Song, S. et al. Nat. Med. 22, 397–403 (2016).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Eric Vivier.

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E.V. is a co-founder and shareholder of Innate-Pharma.

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Vély, F., Golub, R. & Vivier, E. HLA-Fatal attraction. Nat Immunol 17, 1012–1014 (2016). https://doi.org/10.1038/ni.3541

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