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Biological sensors shed light on ligand geography

Nature Immunology volume 16, pages 1209–1211 (2015)Cite this article

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Small, soluble, ubiquitous ligands are difficult to visualize. Schwab and colleagues have created a functional receptor reporter that gauges the in vivo concentration, location and biological action of sphingolipids.

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Figure 1: Detection of S1P signaling in the spleen.

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Authors and Affiliations

  1. the Department of Microbiology and Immunology, and the Department of Surgery, C. Colin Brinkman and Jonathan S. Bromberg are with the Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA, University of Maryland School of Medicine, Baltimore, Maryland, USA, University of Maryland School of Medicine, Baltimore, Maryland, USA.,

    C Colin Brinkman & Jonathan S Bromberg

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  1. C Colin Brinkman
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  2. Jonathan S Bromberg
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Correspondence to Jonathan S Bromberg.

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The authors declare no competing financial interests.

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Brinkman, C., Bromberg, J. Biological sensors shed light on ligand geography. Nat Immunol 16, 1209–1211 (2015). https://doi.org/10.1038/ni.3315

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