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How to become your own worst enemy

Nature Immunology volume 14, pages 315317 (2013) | Download Citation

Persistence is a poorly understood yet widespread outcome of viral infection. A study of RNA viruses in flies now shows that viral fragments endogenized as cDNA during the reverse transcription of retrotransposons provide immunity based on RNA-mediated interference in persistently infected cells.

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Author information

Affiliations

  1. Olivier Voinnet is in the Department of Biology, Swiss Federal Institute of Technology, Zurich, Switzerland.

    • Olivier Voinnet

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Competing interests

The author declares no competing financial interests.

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Correspondence to Olivier Voinnet.

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DOI

https://doi.org/10.1038/ni.2571

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