IFN-γ is a cytokine that is critical for defense against intracellular bacterial pathogens. New work provides evidence that the recognition of bacterial flagellin by the NLRC4 inflammasome in splenic dendritic cells triggers rapid release of IL-18, which leads to IFN-γ production by memory CD8+ T cells.
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Ayres, J., Vance, R. Cellular teamwork in antibacterial innate immunity. Nat Immunol 13, 115–117 (2012). https://doi.org/10.1038/ni.2212
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DOI: https://doi.org/10.1038/ni.2212
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