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Do 5ARIs or alpha blockers more effectively reduce the risk of BPH-related acute urinary retention and surgery?

Nature Clinical Practice Urology volume 1, pages 14–15 (2004)Cite this article

boxed-textBoyle P et al. (2004) 5-Alpha reductase inhibition provides superior benefits to alpha blockade by preventing AUR and BPH-related surgery. Eur Urol 45: 620–627

5ARIs (e.g. finasteride) may more effectively prevent BPH progression to AUR and surgery than older alpha blockers (prazosin, indoramin), but this may not hold for newer agents (alfuzosin, tamsulosin)

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References

  1. Logie GW et al. (2001) Lower urinary tract symptoms suggestive of benign prostatic obstruction—Triumph: the role of general practice databases. Eur Urol 39 (Suppl 3): 42–47

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  2. Clifford GM et al. (2000) How do symptoms indicative of BPH progress in real life practice? The UK experience. Eur Urol 38 (Suppl 1): 48–53

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Acknowledgements

The synopsis was written by Suzanne Farley, Associate Editor, Nature Clinical Practice.

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  1. Consultant Urological Surgeon at Royal Hallamshire Hospital, Sheffield, UK

    Christopher R Chapple

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  1. Christopher R Chapple
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Correspondence to Christopher R Chapple.

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Competing interests

Christopher R Chapple is a consultant for Yamanouchi, Pfizer, GlaxoSmithKline and Schwarz Pharma.

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Chapple, C. Do 5ARIs or alpha blockers more effectively reduce the risk of BPH-related acute urinary retention and surgery?. Nat Rev Urol 1, 14–15 (2004). https://doi.org/10.1038/ncpuro0023

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