Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Adalimumab maintenance therapy improves quality of life in patients with Crohn's disease

Loftus MP et al. (2008) Effects of adalimumab maintenance therapy on health-related quality of life of patients with Crohn's disease: patient-reported outcomes of the CHARM trial. Am J Gastroenterol 103: 3132–3141

Loftus et al. conducted a questionnaire-based study that involved a self-assessment of health-related quality of life in patients with moderate-to-severe Crohn's disease who were enrolled in a phase III, randomized, placebo-controlled trial: CHARM. This trial demonstrated the safety and efficacy of the anti-TNF monoclobal antibody, adalimumab, for Crohn's disease maintenance therapy. Of the 778 patients who completed a 4-week induction with adalimumab, 499 individuals who responded were randomly allocated to placebo, or weekly or fortnightly adalimumab maintenance therapy. Loftus et al. found that by week 4, the average depression score improved from reflecting mild depression at baseline to the normal range, fatigue decreased by a clinically meaningful margin, and general quality of life improved significantly in both its physical and mental components for all three groups. After week 4, however, improvements started to ebb in the placebo group, whereas sustained improvements were observed in the two maintenance-therapy groups. The fortnightly group displayed significant improvements compared with the placebo group at all three postinduction assessments, at weeks 12, 26, and 56.

Depression rates among patients with Crohn's disease and ulcerative colitis are estimated to be three times those of the general population, and baseline fatigue scores in the CHARM cohort were similar to those of patients with cancer-related anemia. These factors underline the importance of maintenance therapy that can improve the quality of life of patients with Crohn's disease.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Adalimumab maintenance therapy improves quality of life in patients with Crohn's disease. Nat Rev Gastroenterol Hepatol 6, 129 (2009). https://doi.org/10.1038/ncpgasthep1350

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpgasthep1350

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing