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What is the safe duration of therapy for patients infected with HCV genotype 6?

Abstract

Very few studies have been published on response to treatment and treatment duration of patients infected with HCV genotype 6. This commentary discusses a study by Nguyen et al. that confirms that standard therapy is associated with a high-virologic response in patients infected with HCV genotype 6. This study also reported that patients who had chronic HCV infection with genotype 6 had a higher rate of sustained virologic response to 48 weeks of treatment with pegylated interferon plus ribavirin than to 24 weeks of treatment with the same combination of drugs. Although these results are promising, they need to be validated in a large prospective study before general conclusions can be drawn.

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References

  1. Fried MW et al. (2002) Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 347: 975–982

    Article  CAS  Google Scholar 

  2. Manns MP et al. (2001) Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358: 958–965

    Article  CAS  Google Scholar 

  3. Zeuzem S et al. (2004) Peginterferon alfa-2b plus ribavirin for the treatment of chronic hepatitis C in previously untreated patients infected with HCV genotypes 2 and 3. J Hepatol 40: 993–999

    Article  CAS  Google Scholar 

  4. Ferenci P et al. (2008) Peginterferon alfa-2a and ribavirin for 24 weeks in hepatitis C type 1 and 4 patients with rapid virological response. Gastroenterology 135: 451–458

    Article  CAS  Google Scholar 

  5. Nguyen MH et al. (2008) Higher rate of sustained virologic response in chronic hepatitis C genotype 6 treated with 48 weeks versus 24 weeks of peginterferon plus ribavirin. Am J Gastroenterol 103: 1131–1135

    Article  CAS  Google Scholar 

  6. Hui CK et al. (2003) Interferon and ribavirin therapy for chronic hepatitis C virus genotype 6: a comparison with genotype 1. J Infect Dis 187: 1071–1074

    Article  CAS  Google Scholar 

  7. Dev AT et al. (2002) Southeast Asian patients with chronic hepatitis C: the impact of novel genotypes and race on treatment outcome. Hepatology 36: 1259–1265

    Article  Google Scholar 

  8. Fung J et al. (2008) Chronic hepatitis C virus genotype 6 infection: response to pegylated interferon and ribavirin. J Infect Dis 198: 808–812

    Article  CAS  Google Scholar 

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Correspondence to Nabil Antaki.

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The authors declare no competing financial interests.

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Antaki, N., Marcellin, P. What is the safe duration of therapy for patients infected with HCV genotype 6?. Nat Rev Gastroenterol Hepatol 6, 78–79 (2009). https://doi.org/10.1038/ncpgasthep1335

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