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Is polyethylene glycol safe and effective for the long-term treatment of patients with chronic constipation?

Nature Clinical Practice Gastroenterology & Hepatology volume 4, pages 656–657 (2007)Cite this article

boxed-textDi Palma JA et al. (2006) An open-label study of chronic polyethylene glycol laxative use in chronic constipation. Aliment Pharmacol Ther 25: 703–708

Polyethylene glycol laxative might be safe and effective for the long-term management of patients with chronic constipation; however, rigorous controlled trials are needed before its use can be established in clinical practice

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References

  1. Ramkumar D and Rao SSC (2005) Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 100: 936–971

    Article  Google Scholar 

  2. Brandt LJ et al. (2005) Systematic review on the management of chronic constipation in North America. Am J Gastroenterol 100 (Suppl 1): S5–S21

    Article  Google Scholar 

  3. Cash BD and Lacy BE (2006) Systematic review: FDA-approved prescription medications for adults with constipation. Gastroenterology and Hepatology 2: 736–749

    PubMed  Google Scholar 

  4. Corazziari E et al. (2000) Long term efficacy, safety, and tolerability of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation. Gut 46: 522–526

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

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  1. Internal Medicine, GI Division, The University of Iowa Hospitals & Clinics, 200 Hawkins Drive, 4612 JCP, Iowa City, IA 52242, USA satish-rao@uiowa.edu

Authors and Affiliations

  1. SSC Rao is a Professor of Medicine and Director of the Neurogastroenterology and GI Motility Program at the University of Iowa Carver College of Medicine, Iowa City, IA, USA.,

    Satish SC Rao

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Competing interests

SSC Rao is a Consultant, is on the Speaker's bureau for, and has received research support from Novartis and Takeda.

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Rao, S. Is polyethylene glycol safe and effective for the long-term treatment of patients with chronic constipation?. Nat Rev Gastroenterol Hepatol 4, 656–657 (2007). https://doi.org/10.1038/ncpgasthep0976

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