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Which children with idiopathic short stature should receive growth hormone therapy?

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References

  1. 1

    Rappold G et al. (2002) Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature. J Clin Endocrinol Metab 87: 1402–1406

    CAS  Article  PubMed  Google Scholar 

  2. 2

    Shanske AL et al. (2007) Unique deletion in exon 5 of SHOX gene in a patient with idiopathic short stature. Horm Res 67: 61–66

    CAS  PubMed  Google Scholar 

  3. 3

    Hintz RL et al. (1999) Effect of growth hormone treatment on adult height of children with idiopathic short stature. Genentech Collaborative Group. N Engl J Med 340: 502–507

    CAS  Article  PubMed  Google Scholar 

  4. 4

    Kemp SF et al. (2005) Efficacy and safety results of long-term growth hormone treatment of idiopathic short stature. J Clin Endocrinol Metab 90: 5247–5253

    CAS  Article  PubMed  Google Scholar 

  5. 5

    Leschek EW et al. (2004) Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 89: 3140–3148

    CAS  Article  PubMed  Google Scholar 

  6. 6

    van Dijk M et al. (2007) Risk factors for diabetes mellitus type 2 and metabolic syndrome are comparable for previously growth hormone-treated young adults born small for gestational age (SGA) and untreated short SGA controls. J Clin Endocrinol Metab 92: 160–165

    CAS  Article  PubMed  Google Scholar 

  7. 7

    Ross JL et al. (2004) Psychological adaptation in children with idiopathic short stature treated with growth hormone or placebo. J Clin Endocrinol Metab 89: 4873–4878

    CAS  Article  PubMed  Google Scholar 

  8. 8

    Dickinson HO et al. (2007) Self-reported quality of life of 8–12-year-old children with cerebral palsy: a cross sectional European study. Lancet 369: 2171–2178

    Article  PubMed  Google Scholar 

  9. 9

    Ranke MB et al. (2007) Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature. Horm Res 68: 53–62

    CAS  PubMed  Google Scholar 

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Dr Czernichow is a consultant for Ipsen.

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Czernichow, P. Which children with idiopathic short stature should receive growth hormone therapy?. Nat Rev Endocrinol 4, 118–119 (2008). https://doi.org/10.1038/ncpendmet0700

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