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Cannabinoid 1 receptor blockade to treat obesity and cardiovascular risk factors

Nature Clinical Practice Gastroenterology & Hepatology volume 2, pages 252–253 (2005)Cite this article

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Van Gaal LF et al. (2005) Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365: 1389–1397

The discovery of the endocannabinoid system, thought to be involved in the regulation of food intake and adipogenesis, has encouraged research into its potential role in the fight against obesity. Indeed, pharmacologic blockade of the cannabinoid 1 receptor leads to weight loss and improvement of metabolic abnormalities in obese mice. A study published in The Lancet now suggests that this approach might also prove useful in humans.

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  • 17 May 2018

    This article was published with the same DOI as a previous publication. A new DOI has been assigned and registered at Crossref, and has been corrected in the article.

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Cannabinoid 1 receptor blockade to treat obesity and cardiovascular risk factors. Nat Rev Gastroenterol Hepatol 2, 252–253 (2005). https://doi.org/10.1038/ncpcardio0207x

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