Probe molecules with systemic activity remain rare, and, as was realized in the pre-molecular era, even their off-target activity can illuminate biology. A study reporting a screen of over 600 kinase inhibitors found nine with bromodomain inhibitory activity and has implications for mechanism and compound optimization.
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Shoichet, B. Follow your lead. Nat Chem Biol 10, 244–245 (2014). https://doi.org/10.1038/nchembio.1484
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DOI: https://doi.org/10.1038/nchembio.1484
