Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Revolving around constriction by ESCRT-III

The endosomal sorting complex required for transport (ESCRT)-III is critical for membrane abscission; however, the mechanism underlying ESCRT-III-mediated membrane constriction remains elusive. A study of the dynamic assembly and disassembly of the ESCRT-III machinery in vitro and in vivo now suggests that the turnover of the observed spiralling filaments is critical for membrane abscission during cytokinesis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Dynamic ESCRT-III and revolving FtsZ ring-like filaments caused by subunit turnover.

References

  1. 1

    Henne, W. M., Buchkovich, N. J. & Emr, S. D. Dev. Cell 21, 77–91 (2011).

    CAS  Article  Google Scholar 

  2. 2

    Alonso, Y. A. M., Migliano, S. M. & Teis, D. FEBS J. 283, 3288–3302 (2016).

    Article  Google Scholar 

  3. 3

    Schöneberg, J., Lee, I. H., Iwasa, J. H. & Hurley, J. H. Nat. Rev. Mol. Cell Biol. 18, 5–17 (2017).

    Article  Google Scholar 

  4. 4

    Hurley, J. H. EMBO J. 34, 2398–2407 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Chiaruttini, N. et al. Cell 163, 866–879 (2015).

    CAS  Article  Google Scholar 

  6. 6

    Mierzwa, B. E. et al. Nat. Cell Biol. 19, 787–798 (2017).

    CAS  Article  Google Scholar 

  7. 7

    Lindås, A. C., Karlsson, E. A., Lindgren, M. T., Ettema, T. J. & Bernander, R. Proc. Natl Acad. Sci. USA 105, 18942–18946 (2008).

    Article  Google Scholar 

  8. 8

    Szwedziak, P., Wang, Q., Bharat, T. A., Tsim, M. & Löwe, J. Elife 3, e04601 (2014).

    Article  Google Scholar 

  9. 9

    Mingorance, J. et al. J. Biol. Chem. 280, 20909–20914 (2005).

    CAS  Article  Google Scholar 

  10. 10

    Arumugam, S., Petrášek, Z. & Schwille, P. Proc. Natl Acad. Sci. USA 111, E1192–E1200 (2014).

    CAS  Article  Google Scholar 

  11. 11

    Loose, M. & Mitchison, T. J. Nat. Cell Biol. 16, 38–46 (2014).

    CAS  Article  Google Scholar 

  12. 12

    Ramirez, D. et al. Preprint at https://doi.org/10.1101/079533 (2016).

  13. 13

    Bisson-Filho, A. W. et al. Science 355, 739–743 (2017).

    CAS  Article  Google Scholar 

  14. 14

    Lan, G., Daniels, B. R., Dobrowsky, T. M., Wirtz, D. & Sun, S. X. Proc. Natl Acad. Sci. USA 106, 121–126 (2009).

    CAS  Article  Google Scholar 

  15. 15

    Lansky, Z. et al. Cell 160, 1159–1168 (2015).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Petra Schwille.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Franquelim, H., Schwille, P. Revolving around constriction by ESCRT-III. Nat Cell Biol 19, 754–756 (2017). https://doi.org/10.1038/ncb3569

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing