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Revolving around constriction by ESCRT-III

The endosomal sorting complex required for transport (ESCRT)-III is critical for membrane abscission; however, the mechanism underlying ESCRT-III-mediated membrane constriction remains elusive. A study of the dynamic assembly and disassembly of the ESCRT-III machinery in vitro and in vivo now suggests that the turnover of the observed spiralling filaments is critical for membrane abscission during cytokinesis.

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Figure 1: Dynamic ESCRT-III and revolving FtsZ ring-like filaments caused by subunit turnover.


  1. 1

    Henne, W. M., Buchkovich, N. J. & Emr, S. D. Dev. Cell 21, 77–91 (2011).

    CAS  Article  Google Scholar 

  2. 2

    Alonso, Y. A. M., Migliano, S. M. & Teis, D. FEBS J. 283, 3288–3302 (2016).

    Article  Google Scholar 

  3. 3

    Schöneberg, J., Lee, I. H., Iwasa, J. H. & Hurley, J. H. Nat. Rev. Mol. Cell Biol. 18, 5–17 (2017).

    Article  Google Scholar 

  4. 4

    Hurley, J. H. EMBO J. 34, 2398–2407 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Chiaruttini, N. et al. Cell 163, 866–879 (2015).

    CAS  Article  Google Scholar 

  6. 6

    Mierzwa, B. E. et al. Nat. Cell Biol. 19, 787–798 (2017).

    CAS  Article  Google Scholar 

  7. 7

    Lindås, A. C., Karlsson, E. A., Lindgren, M. T., Ettema, T. J. & Bernander, R. Proc. Natl Acad. Sci. USA 105, 18942–18946 (2008).

    Article  Google Scholar 

  8. 8

    Szwedziak, P., Wang, Q., Bharat, T. A., Tsim, M. & Löwe, J. Elife 3, e04601 (2014).

    Article  Google Scholar 

  9. 9

    Mingorance, J. et al. J. Biol. Chem. 280, 20909–20914 (2005).

    CAS  Article  Google Scholar 

  10. 10

    Arumugam, S., Petrášek, Z. & Schwille, P. Proc. Natl Acad. Sci. USA 111, E1192–E1200 (2014).

    CAS  Article  Google Scholar 

  11. 11

    Loose, M. & Mitchison, T. J. Nat. Cell Biol. 16, 38–46 (2014).

    CAS  Article  Google Scholar 

  12. 12

    Ramirez, D. et al. Preprint at (2016).

  13. 13

    Bisson-Filho, A. W. et al. Science 355, 739–743 (2017).

    CAS  Article  Google Scholar 

  14. 14

    Lan, G., Daniels, B. R., Dobrowsky, T. M., Wirtz, D. & Sun, S. X. Proc. Natl Acad. Sci. USA 106, 121–126 (2009).

    CAS  Article  Google Scholar 

  15. 15

    Lansky, Z. et al. Cell 160, 1159–1168 (2015).

    CAS  Article  Google Scholar 

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Correspondence to Petra Schwille.

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Franquelim, H., Schwille, P. Revolving around constriction by ESCRT-III. Nat Cell Biol 19, 754–756 (2017).

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