Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell forces meet cell metabolism

Nature Cell Biology volume 19, pages 591–593 (2017)Cite this article

Subjects

Epithelial cells form energetically costly cell–cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Force sensed by E-cadherin regulates AMPK activation.

References

  1. Fletcher, D. A. & Mullins, R. D. Nature 463, 485–492 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Leckband, D. E. & de Rooij, J. Annu. Rev. Cell Dev. Biol. 30, 291–315 (2014).

    Article  CAS  PubMed  Google Scholar 

  3. Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

    CAS  PubMed  Google Scholar 

  4. Bernstein, B. W. & Bamburg, J. R. J. Neurosci. 23, 1–6 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Tung, J. C. et al. Free Radic. Biol. Med. 79, 269–280 (2015).

    Article  CAS  PubMed  Google Scholar 

  6. Hu, H. et al. Cell 164, 433–446 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kahn, B. B., Alquier, T., Carling, D. & Hardie, D. G. Cell Metab. 1, 15–25 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Zheng, B. & Cantley, L. C. Proc. Natl Acad. Sci. USA. 104, 819–822 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Bays, J. L., Campbell, H. K., Heidema, C., Sebbagh, M. & DeMali, K. A. Nat. Cell Biol. 19, 724–731 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ng, M. R., Besser, A., Danuser, G. & Brugge, J. S. J. Cell Biol. 199, 545–563 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Woods, A. et al. Curr. Biol. 13, 2004–2008 (2003).

    Article  CAS  PubMed  Google Scholar 

  12. Bays, J. L. et al. J. Cell Biol. 205, 251–263 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hay, N. Nat. Rev. Cancer 16, 635–649 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Chi, H. Nat. Rev. Immunol. 12, 325–338 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Sebbagh, M., Santoni, M.-J., Hall, B., Borg, J.-P. & Schwartz, M. A. Curr. Biol. 19, 37–42 (2009).

    Article  CAS  PubMed  Google Scholar 

  16. Georgiadou, M. et al. J. Cell Biol. 216, 1107–1121 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology, Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, 75390, Texas, USA

    Tadamoto Isogai, Jin Suk Park & Gaudenz Danuser

Authors
  1. Tadamoto Isogai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jin Suk Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gaudenz Danuser
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gaudenz Danuser.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Isogai, T., Park, J. & Danuser, G. Cell forces meet cell metabolism. Nat Cell Biol 19, 591–593 (2017). https://doi.org/10.1038/ncb3542

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3542

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing