Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.
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S.A.O. is a founder, equity holder, and consultant for OptiKira, L.L.C. (Cleveland, Ohio).
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Moore, P., Oakes, S. CPEB4 links the clock and the UPR to protect the liver. Nat Cell Biol 19, 79–81 (2017). https://doi.org/10.1038/ncb3460
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DOI: https://doi.org/10.1038/ncb3460